Highly sensitive electrochemical azaperone sensor based on magnetic silica –NH2-CS2 in the ostrich meat and rat plasma and its comparison with HPLC–MS/MS

Abstract Azaperone is a very important phenylbutanone-based neurotransmitter used in the treatment of some animal (veterinary) clinics. This compound has various nerve and tendon stabilizing agents on livestock animals. Muscular injection azaperone to reduce stress their acting. In present work, Fe 3 O 4 @SiO 2 -NH /CS nanocomposite was synthesized thoroughly characterized using FE-SEM, FT-IR, XRD technique. The glassy carbon electrode then modified with fabricate sensor named GCE/Fe . application tested for analysis ostrich meat rat plasma. electrochemical behavior differential pulse cyclic voltammetry. Briton–Robinson buffer solution (pH = 6), had an oxidation peak at 0.82 V. Cyclic voltammetry studies indicated that azaprone process irreversible. Experimental variables, including pH accumulation time were optimized by monitoring responses toward current. Measurement technique showed linearity anodic current vs. concentration range 0.01–100.0 μM detection quantification limits nM 10 nM, respectively. Also, effect disturbance species as possible interferers response checked out. Finally, capability fabricated measurement successfully plasma real samples. Graphical abstract